Home Today Oncotarget: Anti-hormonal therapy eligibility in granulosa cell tumors of the ovary

Oncotarget: Anti-hormonal therapy eligibility in granulosa cell tumors of the ovary

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IMAGE: Correlation of FES optimistic and adverse tumour areas (left) with response to hormone therapy (proper). All FES adverse lesions confirmed development after six months hormone therapy, whereas all FES optimistic…
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Credit score: Correspondence to – Joline F. Roze – J.F.Roze-2@umcutrecht.nl

Oncotarget printed “[18F]FDG and [18F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary” which reported that the authors evaluated 22 PET/CTs from recurrent Anti-hormonal granulosa cell tumors (AGCT) sufferers to find out tumor FDG and FES uptake by qualitative and quantitative evaluation.

They included all consecutive sufferers from two tertiary hospitals between 2003-2020.

Expression of ERα and ERβ and mitoses per 2 mm2 have been decided by immunohistochemistry and in comparison with FES and FDG uptake, respectively.

Qualitative evaluation confirmed low-to-moderate FDG uptake in most sufferers, and intense uptake in 2/16. One affected person with intense tumor FDG uptake had a excessive mitotic fee two out of six sufferers confirmed FES uptake on PET/CT at qualitative evaluation.

Inside sufferers, expression of ERα and ERβ various and didn’t appear to correspond with FES uptake.

In a single FES optimistic affected person, tumor areas with FES uptake remained steady or decreased in dimension throughout anti-hormonal therapy, whereas all FES adverse areas progressed.

Dr. Joline F. Roze from The Utrecht University mentioned, “Granulosa cell tumors are a well-defined ovarian most cancers subtype, chargeable for 2-5% of ovarian malignancies with an annual incidence of 0.6–1.0 per 100.000 ladies worldwide.


Granulosa cell tumors are a well-defined ovarian most cancers subtype, chargeable for 2-5% of ovarian malignancies with an annual incidence of 0.6–1.0 per 100.000 ladies worldwide.

Surgical procedure is the mainstay of therapy all through the illness course, as a result of usually restricted results of systemic therapies resembling chemotherapy and hormone therapy.

These research discovered no FDG uptake in two sufferers, average uptake in two sufferers and intense FDG uptake in a single affected person with a bone metastasis.

A earlier examine confirmed that anti-estrogen therapy can lower tumor load in a subset of twenty-two AGCT sufferers.

However, it stays tough to find out the therapy of selection and to determine sufferers which will profit from this therapy.

This examine investigates the worth of FDG-PET/CT for illness monitoring and FES-PET/CT for indicating anti-hormonal therapy eligibility in AGCT sufferers.

The Roze Analysis Crew concluded of their Oncotarget Research Output that it stays a scientific problem to ascertain the optimum timing of therapy for AGCT recurrences.

Moreover PET-CT, different diagnostics resembling detection of circulating tumor DNA in plasma, are at the moment being investigated for illness monitoring and estimation of illness exercise.

Given the low incidence of this illness, performing potential trials in AGCT is tough.

Future potential analysis on FES-PET/CT may elucidate whether or not this imaging device can be utilized to foretell the response to hormonal therapy in AGCT sufferers.

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DOIhttps://doi.org/10.18632/oncotarget.27925


Full textual contenthttps://www.oncotarget.com/article/27925/text/


Correspondence to – Joline F. Roze – J.F.Roze-2@umcutrecht.nl


Key phrases
positron emission tomography (PET),
18F-fluoroestradiol (18F-FES),
18F-fluoro-deoxyglucose (18F-FDG),
granulosa cell tumors (GCTs),
hormone receptors

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